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Screening for iron deficiency in surgical patients based on noninvasive zinc protoporphyrin measurements.

Christoph FüllenbachPhilipp SteinPatricia GlaserChris TriphausSimone LindauSuma ChoorapoikayilElke SchmittKai ZacharowskiGudrun HinterederGeorg HennigChristian HomannHerbert SteppGabriela H SpahnAlexander KasererAndreas SchedlerPatrick MeybohmDonat R Spahn
Published in: Transfusion (2019)
ZnPP-NI appears well suited for an initial IDE screening, informing on the state of erythropoiesis at the point of care without blood drawing and laboratory analysis. Comparison with a multiparameter IDE test revealed that ZnPP-NI values of 40 μmol/mol heme or less allows exclusion of IDE, whereas for 65 μmol/mol heme or greater, IDE is very likely if other causes of increased values are excluded. In these cases (77% of our patients) ZnPP-NI may suffice for a diagnosis, while values in between require analyses of additional iron status parameters.
Keyphrases
  • iron deficiency
  • end stage renal disease
  • newly diagnosed
  • ejection fraction
  • chronic kidney disease
  • metal organic framework
  • peritoneal dialysis
  • transition metal
  • single cell