Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers.
Nishi KothariJamie K TeerAndrea M AbbottThejal SrikumarYonghong ZhangSean J YoderAndrew S BrohlRichard D KimDamon R ReedDavid ShibataPublished in: Cancer (2016)
In this retrospective study, a unique genetic profile was identified for younger patients who have CRC compared with patients who are diagnosed at an older age. These findings should be validated in a larger study and could have an impact on future screening and treatment modalities for younger patients with CRC. Cancer 2016. © 2016 American Cancer Society. Cancer 2016;122:2828-2835. © 2016 American Cancer Society.