Imbalance of flight-freeze responses and their cellular correlates in the Nlgn3 -/y rat model of autism.

Natasha J AnsteyVijayakumar KapgalShashank TiwariThomas C WatsonAnna K H ToftOwen R DandoFelicity H InkpenPaul S BaxterZrinko KozićAdam D JacksonXin HeMohammad Sarfaraz NawazAiman KayenaatAditi BhattacharyaDavid J A WyllieSumantra ChattarjiEmma R WoodOliver HardtPeter C Kind

Published in: Molecular autism (2022)

rats and provide evidence that this is the result of a circuit bias that predisposes flight over freeze responses. Additionally, we demonstrate the first link between PAG dysfunction and ASD/ID. This study provides new insight into potential pathophysiologies leading to anxiety disorders and changes to fear responses in individuals with ASD.

Keyphrases

autism spectrum disorder
intellectual disability
oxidative stress
risk assessment