Sprayable, thermosensitive hydrogels for promoting wound healing based on hollow, porous and pH-sensitive ZnO microspheres.
Wei ZhangHongshu JingQiang NiuZhihua WuYing SunYourong DuanXian-Wen WangPublished in: Journal of materials chemistry. B (2024)
A solvothermal method and the subsequent heat treatment process were developed to fabricate hollow ZnO particles with hierarchical pores on a large scale. The as-obtained hollow, porous ZnO microspheres with tunable sizes, high specific surface areas, pH sensitivity, antibacterial properties, and high adsorption capacities showed significant advantages for drug delivery. Sprayable hydrogels containing hollow, porous ZnO microspheres and curcumin nanoparticles (CNPs) were prepared to accelerate wound healing. The water-dispersed CNPs promoted both the migration of fibroblasts and angiogenesis and an aqueous solution of Pluronic F127 (a temperature-sensitive phase-change hydrogel material) was shown to be an effective choice for medical dressings. The experimental data suggest that hollow, porous ZnO microspheres can be loaded with additional CNPs to achieve continuous long-term therapeutic effects.
Keyphrases
- wound healing
- molecularly imprinted
- metal organic framework
- drug delivery
- room temperature
- quantum dots
- aqueous solution
- tissue engineering
- reduced graphene oxide
- visible light
- solid phase extraction
- highly efficient
- light emitting
- cancer therapy
- healthcare
- drug release
- machine learning
- electronic health record
- ionic liquid
- hyaluronic acid
- gold nanoparticles
- mass spectrometry
- deep learning
- anti inflammatory
- combination therapy