Clinic-radiological features and radiomics signatures based on Gd-BOPTA-enhanced MRI for predicting advanced liver fibrosis.

• Linear or reticular hyperintensity on T2WI, periportal space widening, and diffuse periportal enhancement on HBP can be useful for predicting advanced liver fibrosis. • Clinic-radiological features such as patient age and periportal space widening are the two independent factors predicting advanced fibrosis. • Radiomics signatures derived from Gd-BOPTA-enhanced HBP images offer complementary information to the clinic-radiological model for predicting advanced liver fibrosis.