Placenta mesenchymal stem cell-derived extracellular vesicles alleviate liver fibrosis by inactivating hepatic stellate cells through a miR-378c/SKP2 axis.

Wenjie ZhengSaiyan BianShi QiuColin E BishopMeimei WanNuo XuXieyin SunRussel Clive SequeiraAnthony AtalaZhifeng GuWeixin Zhao

Published in: Inflammation and regeneration (2023)

Pd-MSCs-EVs ameliorated TGF-β1-induced fibrosis by deactivating HSCs in a miR-378c/SKP2-dependent manner, which may be an efficient therapeutic candidate for liver fibrosis.

Keyphrases

liver fibrosis
mesenchymal stem cells
cell proliferation
long non coding rna
long noncoding rna
induced apoptosis
umbilical cord
cell cycle arrest
high glucose
diabetic rats
bone marrow
stem cells
endoplasmic reticulum stress
oxidative stress
cell death
endothelial cells