Blood levels of MCP-1 modulate the genetic risks of Alzheimer's disease mediated by HLA-DRB1 and APOE for Alzheimer's disease.

Jinghan HuangThor D SteinYixuan WangTing Fang Alvin AngQiushan TaoKathryn L LunettaJoseph MassaroSamia C Akhter-KhanJesse MezRhoda AuLindsay A FarrerXiaoling ZhangWei Qiao Qiunull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)

Since HLA-DRB1 and APOE are expressed in the BBB, blood MCP-1 released in the peripheral inflammatory cascade may function as a mediator of the effects of HLA-DRB1 rs9271192-AC/CC and APOE ε4 genotypes on AD pathogenesis in the brain via the BBB pathways.

Keyphrases

cognitive decline
mild cognitive impairment
high fat diet
blood brain barrier
oxidative stress
metabolic syndrome
multiple sclerosis
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