Pentacyclic triterpenes from the leaves extract of Sandoricum koetjape.
Karlina SaptantiLeny HeliawatiElvira HermawatiYana Maolana SyahPublished in: Journal of natural medicines (2022)
Three new pentacyclic triterpenes, trivially named sandkoetjapic acids A-C (1-3), have been isolated from the leaves extract of Sandoricum koetjape, along with the known triterpenes 3-oxo-olean-12-en-29-oic (4), bryonolic (5), and bryononic (6) acids. The structures of the new triterpenes were determined mainly by NMR spectroscopic and mass spectroscopic data. The isolation of these pentacyclic triterpenes in the plant's leaves is for the first time. Preliminary biological evaluation of 1-6 was done against eight receptor tyrosine kinases (RTKs), including EGFR, HER2, HER4 (epidermal growth factor receptor), IGF1R, InsR (insulin receptor), KDR (kinase insert domain receptor), and PDGFRα/-β (platelet-derived growth factor receptor), and their inhibitory properties against β-lactamase. The results showed that none of them were active both as the inhibitors of these RTKs and β-lactamase.
Keyphrases
- epidermal growth factor receptor
- growth factor
- tyrosine kinase
- escherichia coli
- type diabetes
- oxidative stress
- small cell lung cancer
- high resolution
- molecular docking
- advanced non small cell lung cancer
- multidrug resistant
- binding protein
- klebsiella pneumoniae
- machine learning
- cell proliferation
- anti inflammatory
- gram negative
- adipose tissue
- skeletal muscle
- artificial intelligence
- cell wall