miR-449a Is Related to Short-Term Recurrence of Hepatocellular Carcinoma and Inhibits Migration and Invasion by Targeting Notch1.

Bing Han Jiawei HuangZhenjie YangJiaqi ZhangXiaomin WangNing XuHaining MengJunyu WuQiao HuangXi YangRuowu ShenChuandong Sun

Published in: OncoTargets and therapy (2019)

miR-449a is short-term recurrence-related miRNA and inhibits the invasion and metastasis ability of HCC cells by regulating EMT via Notch pathway. miR-449a may be a new effective therapeutic target for HCC.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
induced apoptosis
cell cycle arrest
pi k akt
oxidative stress
signaling pathway
cell death