Histopathological abnormalities in the central arteries and veins of Fontan subjects.
Brandon S HaysMichael BakerAnnie LaibWei TanSebastian UdholmBryan H GoldsteinStephen P SandersAlexander R OpotowskyGruschen R VeldtmanPublished in: Heart (British Cardiac Society) (2017)
Vascular architectural remodelling is common in Fontan patients. The central veins demonstrate profound changes of eccentric intimal expansion and smooth muscle replacement with collagen. The pulmonary demonstrated abnormal intimal proliferation, and aortic remodelling was characterised by intima lamina thickening and a moderate degree of aortic wall inflammation.
Keyphrases
- smooth muscle
- end stage renal disease
- aortic valve
- ejection fraction
- newly diagnosed
- oxidative stress
- left ventricular
- pulmonary artery
- signaling pathway
- inferior vena cava
- peritoneal dialysis
- prognostic factors
- intellectual disability
- resistance training
- coronary artery
- autism spectrum disorder
- metabolic syndrome
- blood flow