Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy.

Emily HoffmannMirjam GerwingTobias KrählingUwe HansenKatharina KronenbergMax MasthoffChristiane GeyerCarsten HöltkeLydia WachsmuthRegina SchinnerVerena HoerrWalter HeindelUwe KarstMichel EisenblätterBastian MausAnne HelfenCornelius FaberMoritz Wildgruber

Published in: Breast cancer research : BCR (2023)

DCE-MRI enables noninvasive assessment of early changes in tumor vasculature after targeted therapies, revealing different response patterns between tumors with divergent degrees of malignancy. DCE-derived tumor perfusion and permeability parameters may serve as vascular biomarkers that allow for repetitive examination of response to antiangiogenic treatment or immunotherapy.

Keyphrases

contrast enhanced
magnetic resonance imaging
computed tomography
diffusion weighted imaging
combination therapy
young adults