Concise two-step chemical synthesis of molnupiravir.
Vinícius R D PereiraMarco A M BezerraMauro R B P GomezGuilherme M MartinsAdilson D da SilvaKléber Thiago de OliveiraRodrigo O M A de SouzaGiovanni W AmarantePublished in: RSC advances (2022)
A concise synthesis of molnupiravir in a one-pot two-step approach starting from uridine is described. Formally, herein, two sets of one-pot two-reaction steps introducing simplicity for purifications and using chemically available reagents are presented. In this context, molnupiravir was obtained in up to 68% overall yield and multigram-scale. In addition, HPLC analysis showed the molnupiravir purity above 99%.