Role of air pollutants mediated oxidative stress in respiratory diseases.
Giovanni TrainaEzio BolzacchiniMaira BoniniDaniele ContiniParide ManteccaSilvia Maria Elena CaimmiGian Luigi MarsegliaPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2022)
Airborne particulate (PM) components from fossil fuel combustion can induce oxidative stress initiated by reactive oxygen species (ROS) that are strongly correlated with airway inflammation and asthma. A valid biomarker of airway inflammation is fractionated exhaled nitric oxide (FENO). The oxidative potential of PM2.5 can be evaluated with the dithiothreitol (DTT) dosage, which represents both ROS chemically produced and intracellular ROS of macrophages. This correlates with quality indicators of the internal environment and ventilation strategies such as dilution and removal of airborne contaminants.
Keyphrases
- reactive oxygen species
- particulate matter
- oxidative stress
- air pollution
- dna damage
- nitric oxide
- lung function
- cell death
- heavy metals
- chronic obstructive pulmonary disease
- induced apoptosis
- ischemia reperfusion injury
- diabetic rats
- drinking water
- liquid chromatography tandem mass spectrometry
- nitric oxide synthase
- small cell lung cancer
- risk assessment
- mechanical ventilation
- respiratory failure
- cystic fibrosis
- gas chromatography
- liquid chromatography
- human health
- heat stress
- mass spectrometry
- signaling pathway
- simultaneous determination
- heat shock protein