A growing animal model for neonatal repair of large diaphragmatic defects to evaluate patch function and outcome.

Mary Patrice EastwoodLuc JoyeuxSavitree PranpanusJohannes Van der MerweEric VerbekenStephanie De VleeschauwerGhislaine Gayan-RamirezJan Deprest

Published in: PloS one (2017)

A primarily patched 3*3cm defect in growing rabbits, under laryngeal mask airway ventilation, enables adequate survival with normal lung function and reduced maximum transdiaphragmatic pressure compared to controls.

Keyphrases

lung function
cystic fibrosis
chronic obstructive pulmonary disease
air pollution
respiratory failure
mechanical ventilation
free survival
intensive care unit
positive airway pressure