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Visible-Light-Promoted Trifluoromethylthiolation and Trifluoromethylselenolation of 1,4-Dihydropyridines.

Xiwen ShanXiaoxing WangEnxue ChenJuyan LiuKui LuXia Zhao
Published in: The Journal of organic chemistry (2022)
We report a metal-free trifluoromethylthiolation and trifluoromethylselenolation of 1,4-dihydropyridines with S -(trifluoromethyl) 4-methylbenzenesulfonothioate and Se -(trifluoromethyl) 4-methylbenzenesulfonoselenoate under visible light irradiation. This transformation was tolerated with a wide range of functional groups and provided an alternative and green strategy for the synthesis of trifluoromethylthioesters and trifluoromethylselenoesters.
Keyphrases
  • visible light
  • radiation therapy
  • radiation induced