A Two-Stage Study Identifies Two Novel Polymorphisms in PRKAG2 Affecting Metformin Response in Chinese Type 2 Diabetes Patients.

Di XiaoJun-Yan LiuSi-Min ZhangRang-Ru LiuJi-Ye YinXue-Yao HanXi LiWei ZhangXiao-Ping ChenHong-Hao ZhouLi-Nong JiZhao-Qian Liu

Published in: Pharmacogenomics and personalized medicine (2021)

Two variants rs2727528 and rs1105842 in PRKAG2, encoding γ2 subunit of AMP-activated protein kinase (AMPK), were found to be associated with metformin response in Chinese T2D patients. These findings may provide some novel information for personalized pharmacotherapy of metformin in China.

Keyphrases

protein kinase
type diabetes
end stage renal disease
newly diagnosed
ejection fraction
prognostic factors
peritoneal dialysis
healthcare
gene expression
skeletal muscle
health information
social media
copy number
smoking cessation
glycemic control
patient reported