Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.
Mohammed A AssiriSamantha R RoyPeter S HarrisHadi AliYongliang LiangColin T ShearnDavid J OrlickyJames R RoedeMatthew D HirscheyDonald S BackosKristofer S FritzPublished in: Alcoholism, clinical and experimental research (2017)
Overall, the findings presented in this study support a role for EtOH-induced lysine acetylation as an adverse posttranslational modification within the mitochondria that directly impacts SOD2 charge state and activity. Last, the data presented here indicate that protein hyperacetylation may be a major factor contributing to an imbalance in hepatic redox homeostasis due to chronic EtOH metabolism.