Fluorene exposure among PAH-exposed workers is associated with epigenetic markers related to lung cancer.

Ayman AlhamdowYona J EssigAnnette M KraisPer GustavssonHåkan TinnerbergChristian H LindhJessika HagbergPål GraffMaria AlbinKarin Broberg

Published in: Occupational and environmental medicine (2020)

Chimney sweeps and creosote-exposed workers were occupationally exposed to low-molecular-weight PAHs. Increasing fluorene exposure, among chimney sweeps, was associated with lower DNA methylation of F2RL3 and AHRR, markers for increased lung cancer risk. These findings warrant further investigation of fluorene exposure and toxicity.

Keyphrases

dna methylation
gene expression
genome wide
risk assessment
climate change
human health
health risk assessment
copy number
abdominal aortic