Andrographolide alleviates Parkinsonism in MPTP-PD mice via targeting mitochondrial fission mediated by dynamin-related protein 1.

Ji GengWen LiuJian GaoChunhong JiangTing FanYang SunZheng-Hong QinQiang XuWenjie GuoJing Gao

Published in: British journal of pharmacology (2019)

Our findings suggest that andrographolide may protect neurons against rotenone- or MPTP-induced damage in vitro and in vivo through inhibiting mitochondrial fission.

Keyphrases

oxidative stress
diabetic rats
drug induced
high glucose
spinal cord
signaling pathway
cancer therapy
parkinson disease
high fat diet induced
mouse model
metabolic syndrome
adipose tissue