Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration.

Chen-Yang TaoXiao-Ling WuShu-Shu SongZheng TangYu-Fu ZhouMeng-Xin TianXi-Fei JiangYuan FangGui-Qi ZhuRun HuangWei-Feng QuJun GaoTian-Hao ChuRui YangJia-Feng ChenQian-Fu ZhaoZhen-Bin DingZhi DaiJian ZhouWei-Ren LiuYing-Hong ShiJia Fan

Published in: Cellular oncology (Dordrecht, Netherlands) (2024)

The findings from this study demonstrate the anticancer activity of GPX8 in HCC by inactivating the Hsc70/AKT pathway. The results suggest a possible therapeutic target for HCC.

Keyphrases

signaling pathway
cell proliferation
stem cells
epithelial mesenchymal transition
cancer stem cells