Oncogenetic landscape of lymphomagenesis in coeliac disease.

Sascha CordingLudovic LhermitteGeorgia MalamutSofia BerrabahAmélie TrinquandNicolas GueganPatrick VillareseSophie KaltenbachBertrand MeresseSherine KhaterMichael DussiotMarc BrasMorgane CheminantBruno TessonChristine Bole-FeysotJulie BruneauThierry Jo MolinaDavid SibonElizabeth MacintyreOlivier HermineChristophe CellierVahid AsnafiNadine Cerf-Bensussannull null

Published in: Gut (2021)

Mutations activating the JAK1-STAT3 pathway appear to be the main drivers of CeD-associated lymphomagenesis. In concert with mutations in negative regulators of NF-κB, they may favour the clonal emergence of malignant lymphocytes in the cytokine-rich coeliac intestine. The identified mutations are attractive therapeutic targets to treat RCDII and block progression towards EATL.

Keyphrases

signaling pathway
oxidative stress
transcription factor
lps induced
single cell
pi k akt
immune response
cell proliferation