The structurally diverse phytocannabinoids cannabichromene, cannabigerol and cannabinol significantly inhibit amyloid β-evoked neurotoxicity and changes in cell morphology in PC12 cells.

These findings highlight the neuroprotective activity of cannabichromene, cannabigerol and cannabinol as novel phytocannabinoids associated with variable effects on Aβ-evoked neurite damage and inhibition of amyloid β aggregation.