Tau pathology associates with in vivo cortical thinning in Lewy body disorders.
Nicola SpotornoDavid G CoughlinChristopher A OlmDavid WolkSanjeev N VaishnaviLeslie M ShawNabila DahodwalaJames F MorleyJohn E DudaAndres F DeikMeredith A SpindlerAlice Chen-PlotkinEdward B LeeJohn Q TrojanowskiCorey T McMillanDaniel WeintraubMurray GrossmanDavid John IrwinPublished in: Annals of clinical and translational neurology (2020)
LBD+AD is characterized by temporal neocortical thinning on MRI, and cortical thinning directly correlated with post-mortem histopathologic burden of tau, suggesting that tau pathology influences the pattern of neurodegeneration in LBD.