Bile Acid Diarrhea in Adults and Adolescents.
Michael CamilleriSamuel NurkoPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2021)
The objective of this review is to summarize the diagnosis of BAD in adults and adolescents. In addition to 75 SeHCAT retention for diagnosis of BAD, studies have validated fasting serum 7αC4 and FGF-19, respectively, by-product and inhibitor of hepatic bile acid synthesis, as well as fecal bile acid measurements. These assays are widely available through reference laboratories, and they are being simplified (eg, measurement of primary fecal bile acids in a random stool sample). BAD has also been identified as a co-factor contributing to persistent diarrhea in other diseases in remission including inflammatory bowel disease, microscopic colitis, celiac disease, and neuroendocrine tumors. In summary, advances in diagnosis of BAD provide opportunities for generalists and pediatric and adult gastroenterologists to provide targeted treatment for BAD presenting as chronic non-bloody diarrhea.
Keyphrases
- young adults
- celiac disease
- neuroendocrine tumors
- irritable bowel syndrome
- physical activity
- clostridium difficile
- ulcerative colitis
- type diabetes
- insulin resistance
- blood glucose
- blood pressure
- cancer therapy
- rheumatoid arthritis
- systemic lupus erythematosus
- combination therapy
- smoking cessation
- single cell
- replacement therapy