Increased systemic and adipose 11β-HSD1 activity in idiopathic intracranial hypertension.
Connar Stanley James WestgateKeira MarkeyJames L MitchellAndreas YiangouRishi SinghalPaul StewartJeremy W TomlinsonGareth G LaverySusan P MollanAlexandra Jean SinclairPublished in: European journal of endocrinology (2022)
The study demonstrates that in IIH, there is a phenotype of elevated systemic and adipose 11β-HSD1 activity in excess to that mediated by obesity. Bariatric surgery to induce weight loss was associated with reductions in 11β-HSD1 activity and decreased ICP. These data reflect new insights into the IIH phenotype and further point toward metabolic dysregulation as a feature of IIH.
Keyphrases
- weight loss
- bariatric surgery
- insulin resistance
- adipose tissue
- blood pressure
- roux en y gastric bypass
- metabolic syndrome
- obese patients
- type diabetes
- gastric bypass
- machine learning
- electronic health record
- skeletal muscle
- high fat diet induced
- optical coherence tomography
- neural network
- drug induced
- artificial intelligence
- arterial hypertension