Impact of liver fibrosis on the relative abundance of urease-positive Streptococcus salivarius group from saliva in patients with chronic liver disease.

Forty-five patients identified using the multiplex PCR for the 16S rRNA gene were tested using the multiplex PCR for the coaE gene. Confirming the strains detected in each of the 45 patients, urease-positive S.salivarius was detected in 28 patients (62%), urease-negative S. salivarius in 25 patients (56%), and urease-positive Streptococcus vestibularis in 12 patients (27%). There was no patient with urease-negative S. vestibularis. The urease-positive rate of the S. salivarius group in the cirrhosis and non-cirrhosis groups were 82.2% and 39.2%, respectively. The liver cirrhosis group had a higher urease positivity rate than the non-cirrhotic group. (P<0.001) CONCLUSIONS: Liver fibrosis influences the frequency of a urease-positive S.salivarius group isolated from oral saliva. This article is protected by copyright. All rights reserved.