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Suberitolactams A-D and Suberitopyridines A-B: New γ-lactam and Pyridine Alkaloids Isolated from the South China Sea Sponge Pseudospongosorites suberitoides.

Zhe WangGuo-Qiang LiHan-Ting Zhang
Published in: Chemistry & biodiversity (2024)
Four new γ-lactam alkaloids, suberitolactams A-D (1-4), two new pyridine alkaloids, suberitopyridines A-B (7-8), and two known compounds (5-6) were isolated from the South China Sea sponge Pseudospongosorites suberitoides. The structures were elucidated by detailed 1D and 2D NMR experiments along with HRESIMS analysis and single crystal X-ray diffraction. Compounds 1 and 8 showed moderate to weak antiviral activity against H1 N1 virus with IC 50 values of 27.6 and 13.3 μM, respectively.
Keyphrases
  • high resolution
  • magnetic resonance
  • gram negative
  • high intensity
  • electron microscopy
  • computed tomography
  • magnetic resonance imaging
  • mass spectrometry
  • multidrug resistant
  • crystal structure