PM-Scl and Th/To in systemic sclerosis: a comparison of different autoantibody assays.
Christopher A MecoliL Gutierrez-AlamilloQ YangM SampedroA WoodsL K HummersF WigleyA A ShahL Casciola-RosenPublished in: Clinical rheumatology (2021)
• For less common SSc autoantibody specificities, some discordances exist between IP and Euroimmun LIA. • The best performing thresholds for defining anti-PM-Scl positivity were both PM75 and PM100 ≥ 15/+ on Euroimmun. • For Th/To, a two-step approach (Euroimmun to maximize sensitivity, confirmatory assay to increase specificity) is suggested.