The Interplay between Obesity and Inflammation.
Ilinca Savulescu-FiedlerRazvan MihalceaSerban DragosloveanuCristian ScheauRadu Octavian BazAna CăruntuAndreea-Elena ScheauConstantin CaruntuSerban Nicolae BeneaPublished in: Life (Basel, Switzerland) (2024)
Obesity is an important condition affecting the quality of life of numerous patients and increasing their associated risk for multiple diseases, including tumors and immune-mediated disorders. Inflammation appears to play a major role in the development of obesity and represents a central point for the activity of cellular and humoral components in the adipose tissue. Macrophages play a key role as the main cellular component of the adipose tissue regulating the chronic inflammation and modulating the secretion and differentiation of various pro- and anti-inflammatory cytokines. Inflammation also involves a series of signaling pathways that might represent the focus for new therapies and interventions. Weight loss is essential in decreasing cardiometabolic risks and the degree of associated inflammation; however, the latter can persist for long after the excess weight is lost, and can involve changes in macrophage phenotypes that can ensure the metabolic adjustment. A clear understanding of the pathophysiological processes in the adipose tissue and the interplay between obesity and chronic inflammation can lead to a better understanding of the development of comorbidities and may ensure future targets for the treatment of obesity.
Keyphrases
- weight loss
- insulin resistance
- adipose tissue
- oxidative stress
- metabolic syndrome
- bariatric surgery
- weight gain
- type diabetes
- high fat diet induced
- roux en y gastric bypass
- high fat diet
- signaling pathway
- gastric bypass
- end stage renal disease
- physical activity
- skeletal muscle
- chronic kidney disease
- newly diagnosed
- immune response
- peritoneal dialysis
- epithelial mesenchymal transition
- obese patients
- climate change
- anti inflammatory
- patient reported outcomes