Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lung.
Ioannis MorianosAikaterini TsitsopoulouKonstantinos PotarisDimitrios ValakosOurania FariGiannis VatsellasClementine BostantzoglouAndreas PhotiadesMina GagaGeorgina XanthouMaria SemitekolouPublished in: Journal of experimental & clinical cancer research : CR (2021)
In this study, we introduce activin-A as a novel immunomodulatory factor in the lung tumor microenvironment, which bestows exhausted CD4+ T cells with effector properties.
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