Emergence and maintenance of actionable genetic drivers at medulloblastoma relapse.

Stacey RichardsonRebecca M HillChristopher KuiJanet C LindseyYura GrabovksaClaire KeelingLouise PeaseMatthew BashtonStephen CrosierMaria VinciNicolas AndréDominique Figarella BrangerJordan R HansfordMaria LastowskaKrzysztof ZakrzewskiMette JorgensenJessica C PicklesMichael D TaylorStefan M PfisterStephen B WhartonBarry PizerAntony MichalskiAbhijit JoshiThomas S JacquesDebbie HicksEdward C SchwalbeDaniel WilliamsonVijay RamsawamiSimon BaileySteven C Clifford

Published in: Neuro-oncology (2021)

rMB is defined by the emergence of novel events and pathways, in concert with selective maintenance of established genetic drivers. Together, these define the actionable genetic landscape of rMB and provide a basis for improved clinical management and development of stratified therapeutics, across disease-course.

Keyphrases

genome wide
copy number
dna methylation
gene expression
single cell