Reproducibility of Ocular Surface Staining in the Assessment of Sjögren Syndrome-Related Keratoconjunctivitis Sicca: Implications on Disease Classification.
Astrid RasmussenDonald U StoneC Erick KaufmanKimberly S HefnerNicole R FramRhea L SiatkowskiAndrew J W HuangJames ChodoshPablo T RasmussenDustin A FifeNathan PezantKiely GrundahlLida RadfarDavid M LewisMichael H WeismanSwamy VenuturupalliDaniel J WallaceNelson L RhodusMichael T BrennanCourtney G MontgomeryChristopher J LessardR Hal ScofieldKathy L SivilsPublished in: ACR open rheumatology (2019)
Ocular surface staining scores are useful for SS research classification; however, they are subject to significant interrater and intrasubject variability, which could result in changes in classification in 5%-10% of all subjects. These results highlight the need for objective and reproducible markers of disease that have thus far remained elusive for SS.