ERK/HIF-1α/VEGF pathway: a molecular target of ELABELA (ELA) peptide for attenuating cardiac ischemia-reperfusion injury in rats by promoting angiogenesis.

Kamran RakhshanMasoomeh SharifiFatemeh RamezaniYaser AziziNahid Aboutaleb

Published in: Molecular biology reports (2022)

Collectively, ELA peptide has ability to reduce myocardial I/R injury by promoting angiogenesis and reducing cardiac interstitial fibrosis through activating ERK/HIF-1α/VEGF pathway.

Keyphrases

endothelial cells
vascular endothelial growth factor
signaling pathway
left ventricular
pi k akt
cell proliferation
heart failure
single molecule