Effects of a Global Rab27a Null Mutation on Murine PVAT and Cardiovascular Function.
Ashley SoucyChristian PottsAbigail KaijaAnne HarringtonMarissa McGilvreyGeorge L SutphinRon KorstanjeBenjamin TeroJacob SeekerIlka PinzCalvin VaryLarisa RyzhovaLucy LiawPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Global RAB27A loss impacted perivascular adipose tissue and thoracic aorta proteomic signatures, altered vasocontractile responses, and decreased left ventricular ejection fraction in mice.
Keyphrases
- ejection fraction
- aortic stenosis
- adipose tissue
- left ventricular
- aortic valve
- transcatheter aortic valve replacement
- spinal cord
- insulin resistance
- heart failure
- high fat diet induced
- high fat diet
- pulmonary artery
- type diabetes
- hypertrophic cardiomyopathy
- coronary artery disease
- gene expression
- mitral valve
- pulmonary hypertension
- cardiac resynchronization therapy
- coronary artery
- percutaneous coronary intervention
- label free
- acute coronary syndrome
- spinal cord injury
- wild type
- dna methylation