Acute intranasal treatment with nerve growth factor limits the onset of traumatic brain injury in young rats.
Luigi ManniEleonora LeottaIlia MollicaAnnalucia SerafinoAnnabella PignataroIllari SalvatoriGiorgio ContiAntonio ChiarettiMarzia SoligoPublished in: British journal of pharmacology (2023)
Intranasal application of NGF was effective in decreasing the motor dysfunction and neuroinflammation in the brain of young rats in our model of TBI. This work forms an initial pre-clinical evaluation of the potential of early intranasal NGF treatment in preventing and limiting the disabling outcomes of TBI, a clinical condition that remains one of the unsolved problems of paediatric neurology.
Keyphrases
- traumatic brain injury
- growth factor
- emergency department
- intensive care unit
- mental health
- oxidative stress
- severe traumatic brain injury
- liver failure
- type diabetes
- middle aged
- skeletal muscle
- metabolic syndrome
- cognitive impairment
- brain injury
- inflammatory response
- extracorporeal membrane oxygenation
- white matter
- acute respiratory distress syndrome
- human health
- subarachnoid hemorrhage
- mechanical ventilation