Mould allergen Alt a 1 spiked with the micronutrient retinoic acid reduces Th2 response and ameliorates Alternaria allergy in BALB/c mice.

Aila Fakhimahmadi Franziska Roth-Walter Gerlinde Hofstetter Markus Wiederstein Sebastian A JensenMarkus BergerNathalie SzepannekRodolfo Bianchini Isabella Pali-Schöll Erika Jensen-Jarolim Karin Hufnagl

Published in: Allergy (2024)

Holo-Alt a 1 binding to RA was able to alleviate Th2 immunity in vitro, modulate an ongoing Th2 response and prevent anaphylactic symptoms in vivo, presenting a novel option for improving allergen-specific immunotherapy in Alternaria allergy.

Keyphrases

rheumatoid arthritis
mouse model
type diabetes
metabolic syndrome
infectious diseases
skeletal muscle