A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating K v 1.1.

Lin ZhouKang WangYuxiang XuBin-Bin DongDeng-Chang WuZhao-Xiang WangXin-Tai WangXin-Yu CaiJin-Tao YangRui ZhengWei ChenYing ShenJian-She Wei

Published in: Cell & bioscience (2023)

These results describe a role of secretion-defective LGI1 in maintaining neuronal excitability and reveal a new mechanism in the pathology of LGI1 mutation-related epilepsy.

Keyphrases

temporal lobe epilepsy
genome wide
single cell
transcranial direct current stimulation
gene expression
dna methylation
subarachnoid hemorrhage