Cobalt-Catalyzed Enantioselective Reductive Amination of Ketones with Hydrazides.
Tiantian ChenYanhua HuXuyang TangYashi ZouLiangming WeiZhenfeng ZhangWanbin ZhangPublished in: Organic letters (2023)
An efficient cobalt-catalyzed asymmetric reductive amination of ketones with hydrazides has been realized, directly producing valuable chiral hydrazines in high yields and enantioselectivities (up to 98% enantiomeric excess).