Intranasal Delivery of miR-155-5p Antagomir Alleviates Acute Seizures Likely by Inhibiting Hippocampal Inflammation.

Xu ZhouJun ChenHua TaoYujie CaiLidan HuangHaihong ZhouYanyan ChenLili CuiWangtao ZhongKeshen Li

Published in: Neuropsychiatric disease and treatment (2020)

These findings demonstrate that intranasal delivery of miR-155-5p antagomir alleviated acute seizures, likely by blocking hippocampal inflammation. However, other potential mechanisms of the effects of miR-155-5p antagomir and its long-term safety for epilepsy treatment remain to be investigated.

Keyphrases

temporal lobe epilepsy
liver failure
oxidative stress
respiratory failure
aortic dissection
drug induced
cerebral ischemia
intensive care unit
combination therapy
high resolution
acute respiratory distress syndrome
smoking cessation