Identification and rescue of a novel TUBB8 mutation that causes the first mitotic division defects and infertility.

Yanping JiaKunming LiCaihong ZhengYuanyuan TangDandan BaiJiqing YinFengli ChiYalin ZhangYanhe LiZhifen TuYu WangJiaping PanShanshan LiangYi GuoJingling RuanPengcheng KongBi WuYe HuHong WangWenqiang LiuXiaoming TengShao-Rong Gao

Published in: Journal of assisted reproduction and genetics (2020)

Our study not only defines a novel mutation of TUBB8 causing the early cleavage arrest of embryos, but also provides an important basis for treating such female infertility in the future.

Keyphrases

cell cycle
polycystic ovary syndrome
type diabetes
metabolic syndrome
insulin resistance
transcription factor