Long-Term Near-Infrared Signal Tracking of the Therapeutic Changes of Glioblastoma Cells in Brain Tissue with Ultrasound-Guided Persistent Luminescent Nanocomposites.
Chiao-Ling ChengMing-Hsien ChanSheng-Jan FengMichael HsiaoRu-Shi LiuPublished in: ACS applied materials & interfaces (2021)
The blood-brain barrier (BBB) is a physical barrier that selectively prevents certain substances from entering the brain through the blood. The BBB protects the brain from germs and causes difficulty in intracranial treatment. The chemotherapy drug temozolomide (TMZ), embedded in nanobubbles (NBs) and combined with persistent luminescent nanoparticles (PLNs), has been used to treat glioblastoma (GBM) effectively through image tracking. Through ultrasound induction, NBs produce cavitation that temporarily opens the BBB. Additionally, the PLNs release near-infrared emission and afterglow, which can penetrate deep tissues and improve the signal-to-noise ratio of bioimages. In this work, the nanosystem crossed the BBB for drug delivery and image tracking over time, allowing the enhancement of the drug's therapeutic effect on GBM. We hope that this nanosystem can be applied to the treatment of different brain diseases by embedding different drugs in NBs.
Keyphrases
- blood brain barrier
- resting state
- white matter
- drug delivery
- cerebral ischemia
- ultrasound guided
- functional connectivity
- induced apoptosis
- quantum dots
- squamous cell carcinoma
- gene expression
- machine learning
- drinking water
- radiation therapy
- cell death
- brain injury
- signaling pathway
- mouse model
- cell proliferation
- air pollution
- cell cycle arrest
- cancer therapy
- locally advanced
- metal organic framework
- newly diagnosed
- carbon nanotubes
- rectal cancer
- replacement therapy
- smoking cessation
- drug release