Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis.
Ru-Hsiu ChengYi-Ping WangJulia Yu-Fong ChangYu-Hwa PanMei-Chi ChangJiiang-Huei JengPublished in: International journal of molecular sciences (2020)
Betel quid (BQ) chewing increased the risk of oral cancer and oral submucous fibrosis (OSMF), an oral premalignant disorder (OPMD) with malignant transformation potential. BQ components such as areca nut (AN), trauma by coarse AN fiber, catechin, copper, alkaloids, stimulated reactive oxygen species (ROS), inflammation and cytotoxicity are suggested to be the contributing factors. They may induce tissue inflammation, proliferation of fibroblasts and collagen deposition, myofibroblast differentiation and contraction, collagen cross-links and inhibit collagen phagocytosis, finally leading to the development of OSMF and oral cancer. These events are mediated by BQ components-induced changes of extracellular matrix (ECM) turnover via regulation of TGF-β1, plasminogen activator inhibitor-1 (PAI-1), cystatin, lysyl oxidase (LOX) and tissue inhibitors of metalloproteinases (TIMPs) and metalloproteinases (MMPs). Genetic susceptibility is also involved in these disease processes. Further understanding the molecular mechanisms of BQ-induced OSMF and oral cancer can be helpful for future disease prevention and treatment.
Keyphrases
- extracellular matrix
- reactive oxygen species
- oxidative stress
- diabetic rats
- high glucose
- genome wide
- bone mineral density
- wound healing
- transforming growth factor
- signaling pathway
- dna damage
- molecular dynamics
- cell death
- copy number
- risk assessment
- current status
- molecular dynamics simulations
- dna methylation
- combination therapy
- gene expression
- liver fibrosis
- human health
- smooth muscle
- trauma patients