Mn-Catalyzed Electrooxidative Radical Cascade Cyclization for the Synthesis of 6-Phosphorylated Quinoxalino[2,1- b ]quinazolin-12-ones.

Due to their important potential medicinal value, chemists are pursuing mild and efficient methods to synthesize structurally diverse quinazolinone derivatives. In this paper, a series of isocyano-tethered N -aryl quinazolinones were designed and synthesized to conduct electrocatalytic radical cascade cyclization reactions with phosphine oxides by utilizing inexpensive Mn II salt as the catalyst. The desired 6-phosphorylated quinoxalino[2,1- b ]quinazolin-12-ones were obtained in moderate to good yields.