An updated overview of the application of CAR-T cell therapy in neurological diseases.
Hesam ShahabifardMahdi ZareiKeihan KookliNazgol Esmalian AfyouniNarges SoltaniSairan MaghsoodiAli AdiliJavad MahmoudiNavid ShomaliSiamak Sandoghchian ShotorbaniPublished in: Biotechnology progress (2023)
Genetically modified immune cells, especially CAR-T cells, have captured the attention of scientists over the past 10 years. In the fight against cancer, these cells have a special place. Treatment for hematological cancers, autoimmune disorders, and cancers must include CAR-T cell therapy. Determining the therapeutic targets, side effects, and use of CAR-T cells in neurological disorders, including cancer and neurodegenerative diseases, is the goal of this study. Due to advancements in genetic engineering, CAR-T cells have become crucial in treating some neurological disorders. CAR-T cells have demonstrated a positive role in treating neurological cancers like Glioblastoma and Neuroblastoma due to their ability to cross the blood-brain barrier and use diverse targets. However, CAR-T cell therapy for MS diseases is being researched and could be a potential treatment option. This study aimed to access the most recent studies and scientific articles in the field of CAR-T cells in neurological diseases and/or disorders.
Keyphrases
- cell therapy
- stem cells
- papillary thyroid
- mesenchymal stem cells
- multiple sclerosis
- cerebral ischemia
- gene expression
- induced apoptosis
- childhood cancer
- working memory
- squamous cell carcinoma
- brain injury
- risk assessment
- subarachnoid hemorrhage
- combination therapy
- cell proliferation
- blood brain barrier
- dna methylation
- lymph node metastasis
- case control
- oxidative stress