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Massive expansion of sex-specific SNPs, transposon-related elements, and neocentromere formation shape the young W-chromosome from the mosquitofish Gambusia affinis.

Stefan MüllerKang DuYann GuiguenMaria PichlerShinichi NakagawaMatthias StöckManfred SchartlDunja K Lamatsch
Published in: BMC biology (2023)
The G. affinis W-chromosome exhibits characteristic genomic properties of an evolutionary young sex chromosome. Strikingly, the observed sex-specific changes in the genomic landscape are confined to the W long arm, which is separated from the rest of the W-chromosome by a neocentromere acquired during sex chromosome evolution and may thus have become functionally insulated. In contrast, W short arm sequences were apparently shielded from repeat-driven differentiation, retained Z-chromosome like genomic features, and may have preserved pseudo-autosomal properties.
Keyphrases
  • copy number
  • genome wide
  • magnetic resonance
  • dna methylation
  • middle aged
  • gene expression
  • magnetic resonance imaging
  • single cell