Recent single-cell RNA sequencing has offered an unprecedented view of pituitary cell transcriptomic profiles. In this review, these new data are briefly discussed and compared with the classical literature, focusing on pituitary corticotrophs. These cells are introduced by discussing their marker genes, followed by a review of G protein-coupled receptor gene expression, heterotrimeric G protein genes, and genes encoding signaling pathways downstream of G proteins: adenylate cyclases, phosphodiesterases, phospholipases, and protein kinases. The expression patterns of enzyme-linked plasma membrane and nuclear hormone receptor genes was also analyzed. The overview of these selected groups of genes sheds new light on corticotrophic receptors and their signaling pathways and provides guidance for further basic and clinical research by identifying genes that not been studied so far.
Keyphrases
- single cell
- genome wide
- gene expression
- bioinformatics analysis
- rna seq
- genome wide identification
- signaling pathway
- dna methylation
- induced apoptosis
- high throughput
- oxidative stress
- machine learning
- cell proliferation
- long non coding rna
- epithelial mesenchymal transition
- electronic health record
- transcription factor
- cell cycle arrest
- artificial intelligence
- deep learning
- cell death
- mesenchymal stem cells
- small molecule
- pi k akt
- big data
- growth hormone
- protein protein