Inversion symmetry of DNA k-mer counts: validity and deviations.

Our IS-Poisson model agrees well with genomic data, and accounts for the universal behavior of k-limits. For low k we point out minute, yet significant, deviations from the model, including excess of counts of nucleotides T vs A and G vs C on positive strands of human chromosomes. Interestingly, this correlates with a significant (but small) excess of genes on the same positive strands.