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Phytochemical Investigation of the Roots of Ipomoea asarifolia and Antiproliferative Activity of the Isolated Compounds against Multiple Myeloma Cells.

Noémie SarauxDeniza ImeriLuis Quirós-GuerreroSoumana KarimouPhilippe ChristenMuriel Cuendet
Published in: Journal of natural products (2021)
Ipomoea asarifolia is a herbaceous plant belonging to the family Convolvulaceae and is native to tropical regions of Africa, America, and Asia. A dichloromethane root extract showed antiproliferative activity against multiple myeloma cells (RPMI 8226). The phytochemical investigation led to the isolation of 15 compounds. Compounds 1 - 4 , named (4 S ,8 S )-1-(furan-3-yl)-9-hydroxy-4,8-dimethylnonane-1,6-dione, isoferulic acid hexadecyl ester, caffeic acid hexadecyl ester, and asarifolin I, respectively, are described for the first time. The structures of these molecules were established from their NMR, UV, IR spectroscopic, and MS data. 4-Hydroxycinnamic acid hexadecyl ester ( 5 ), 4-hydroxycinnamic acid octadecyl ester ( 6 ), 4-hydroxycinnamic acid eicosyl ester ( 7 ), caffeic acid octadecyl ester ( 8 ), pescapreins III, IV, XXI, XXIII, XXV, and XXVI ( 9 - 14 ), and stoloniferin III ( 15 ) were also isolated. All compounds were tested against a multiple myeloma cell line (RPMI 8226). When their IC 50 value was lower than 10 μM, the compounds were also tested against two other multiple myeloma cell lines, MM.1S and MM.1R. Compound 3 was the most potent, with an IC 50 value of 3.0 μM against RPMI 8226 cells.
Keyphrases
  • multiple myeloma
  • induced apoptosis
  • cell cycle arrest
  • oxidative stress
  • magnetic resonance
  • endoplasmic reticulum stress
  • high resolution
  • electronic health record
  • big data
  • anti inflammatory