Atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative damage and apoptosis induced by ovarian ischaemia/reperfusion injury.

O A AfolabiM A HamedD C AnyoguD H AdeyemiA F OdetayoRoland Eghoghosoa Akhigbe

Published in: Redox report : communications in free radical research (2022)

For the first time, this study revealed that atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative injury, inflammation, and apoptosis induced by ovarian ischaemia/reperfusion injury.

Keyphrases

cell death
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
induced apoptosis
acute myocardial infarction
cell proliferation
signaling pathway
single cell
acute coronary syndrome
percutaneous coronary intervention
brain injury
pi k akt