The evaluation of a tissue-engineered cardiac patch seeded with hips derived cardiac progenitor cells in a rat left ventricular model.
Yuichi MatsuzakiShinka MiyamotoHideki MiyachiTadahisa SugiuraJames W ReinhardtChang Yu-ChunJacob ZbindenChristopher K BreuerToshiharu ShinokaPublished in: PloS one (2020)
We have developed a surgical method to implant a bioabsorbable scaffold into the left ventricular environment of rats with a high survival rate. Seeded hiPS-CPCs did not differentiate into cardiomyocytes, but the greater number of new blood vessels in seeded patches suggests the presence of cell seeding early in the remodeling process might provide a prolonged effect on neotissue formation. This experiment will contribute to the development of a treatment model for left ventricular failure using iPS cells in the future.
Keyphrases
- left ventricular
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- heart failure
- acute myocardial infarction
- aortic stenosis
- left atrial
- mitral valve
- induced apoptosis
- single cell
- oxidative stress
- stem cells
- cell therapy
- bone marrow
- transcatheter aortic valve replacement
- ejection fraction
- endoplasmic reticulum stress
- soft tissue